Open the .dmg file and drag RustDesk to Applications as below.

Make sure you have quit all running RustDesk. Also make sure you quit the RustDesk service shown on the tray.

Allow RustDesk run

Unlock to changeClick on App Store and identified developers

Enable permissions

Due to macOS security policy change, our api which captures input on local side does not work any more. You have to enable “Input Monitoring” permission on local Mac side. Please follow this

In version 1.2.4, you can try out Input source 2 which can be seen by clicking on keyboard icon on the toolbar.

To capture screen, you need to grant RustDesk Accessibility permission and Screen Recording permission. RustDesk will guide you to the settings window.

RustDesk windowSettings window

If you have enabled it in the settings window, but RustDesk still warns. Please remove RustDesk from the settings windows by the - button, and click on + button, select RustDesk in Applications.
Other helpless attempts:
tccutil reset ScreenCapture com.carriez.RustDesk
tccutil reset Accessibility com.carriez.RustDesk
Reboot is still required.

- and + buttonSelect RustDesk

Please copy above steps for Screen Recording permission.